How Do the Ingredients in Calm Legs Relax Restless Legs?

3 min read

bottle of Calm Legs under microscope

Calm Legs was the first natural supplement to address recently discovered nutrient deficiencies associated with Restless Legs Syndrome (RLS) while helping to reduce symptoms of RLS.

For many, prescription drug therapies fall short. Drugs may cause harsh side effects and carry a risk of dependence, tolerance and withdrawal. Some prescription drugs even create the same nutrient depletions that contribute to restless legs syndrome in the first place.

Each ingredient in the Calm Legs formula has been clinically tested and shown to reduce symptoms of RLS.

 Calm Legs Features


Ingredients & Vitamins for Restless Leg Syndrome

Iron (ferrous fumarate)

Iron Is the most common nutritional deficiency in the world. Iron deficiency can cause RLS by lowering brain dopamine levels. Used successfully for more than 50 years, iron may be the most well-established natural RLS support nutrient. Research has suggested that supplemental iron may produce significant relief from RLS symptoms.[1]

Folic Acid

Folic acid is crucial for maintaining calm, settled legs — especially in deficiency-risk populations like pregnant women and the elderly. In fact, research has suggested that up to 27% of pregnant women experience restless legs symptoms.[2]

Magnesium Oxide

Magnesium calms the nervous system, settling “excitable” neurons while boosting neurotransmitter production. Magnesium also plays a key role in leg muscle relaxation, which is crucial for relief from restless legs. Magnesium can be depleted with too much stress or caffeine. Studies have shown that supplemental magnesium improves quality of sleep and serves as a useful therapy for RLS symptoms.[3][7] 

Vitamin B12 

Restless legs syndrome scientific reviews have reported that B12 deficiency appears to cause restless legs flareups.[7]

Valerian Root

The use of this soothing herb for its relaxation effects can be traced back to ancient Greece and Rome. For those with RLS sleep disruptions from RLS, valerian is clinically shown to accelerate sleep onset, enhance sleep quality and reduce nighttime awakenings. Researchers have suggested that valerian is a safe herb for managing RLS without side effects.[4]

Vitamin C

Restless legs are linked to bad circulation and unhealthy blood vessels. Vitamin C is famous for promoting flexible, healthy blood vessels. Vitamin C also boosts iron absorption, “regenerates” Vitamin E and enhances circulation to the legs and feet. Research has found that vitamin C supplementation brings significant reductions in Restless Legs (RLS) symptoms.[5][7]

Vitamin E

Vitamin E as a restless legs relief promotes flexible arteries, boosts leg circulation, modulates inflammation and supports healthy nervous system function. Vitamin E is an RLS symptom relief multitasker that promotes flexible arteries, boosts leg circulation, modulates inflammation and supports healthy nervous system function. Research has shown that vitamin E supplementation was associated with “prompt and gratifying relief” of nighttime leg cramping.[5][6][7]

Research Studies

[1] O’Keeffe ST, Gavin K, Lavan JN. Iron status and Restless Legs (RLS) syndrome in the elderly. Age and Ageing. 1994 May;23(3):200

[2] Goodman J, et al. Restless Legs Syndrome (RLS) in pregnancy. BMJ. 1988 October 29; 297(6656): 1101–1102.

[3] Hornyak M, et al. Magnesium Therapy for Periodic Leg Movements-related Insomnia and Restless Legs (RLS): An Open Pilot Study. Sleep, Vol. 21, No. 5, 1998

[4] Cuellar N, Ratcliffe J. Does Valerian Improve Sleepiness and Symptom Severity in People With Restless Leg Syndrome? Alternative Therapies, Mar/Apr 2009, Vol. 15, No. 2.

[5] Sagheb MM, et al. Efficacy of vitamins C, E, and their combination for treatment of Restless Legs (RLS) syndrome in hemodialysis patients: A randomized, double-blind, placebo-controlled trial. Sleep Medicine 13 (2012), 542-545.

[6] Ayres S Jr, Mihan R. Leg cramps (systremma0 and “Restless Legs (RLS)” syndrome. Response to vitamin E (tocopherol). Calif Med. 69 Aug;111(2):87-91.

[7] Mitchell U. Non-drug-related aspect of treating Ekbom disease, formerly known as Restless Legs (RLS) syndrome. Neuropsychiatric Disease and Treatment. 2011:7, 251-257.

Are restless legs robbing you of sleep and keeping you from enjoying your favorite activities?

Try the first natural supplement clinically tested and shown to reduce symptoms of RLS.

Learn how the ingredients in Calm Legs relax and calm restless legs