How Do the Ingredients in Flexify Help Relieve Pain and Nourish Joints?

5 min read

Flexify bottle under microscope

Flexify is the most comprehensive natural joint health formula available. Seven ingredients critical to building strong, healthy joints are included in every easy-to-swallow tablet. The ingredients in Flexify have been independently shown to provide relief from joint pain, improve flexibility and support healthy joints.


A natural lubricant found in the cartilage, glucosamine acts as a shock absorber to help minimize joint pain. A study done in 2012[1] demonstrated that glucosamine supplementation significantly reduced the symptoms of osteoarthritis in the lower limbs and delayed the structural progression of osteoarthritis.

Chondroitin Sulfate

Chondroitin attracts fluid to your joints to support cushioning and lubrication. It is a major component of cartilage that gives the joint elasticity; reduces the activity of substances that break down collagen in joints; and assists in the rebuilding of cartilage.[2][3][4][5] In athletes, chondroitin boosts recovery of tissue from exercise or injury to the joints.


MSM (methylsulfonylmethane) is a sulfur-containing building block for cartilage that strengthens joint tissues and helps with elasticity. Research has shown a reduction of symptoms of joint pain, stiffness and decreased flexibility allowing for a better quality of life in individuals with osteoarthritis.[6] A 2004 study found that the combination of MSM with glucosamine provided better and more rapid improvement in patients with osteoarthritis than when either substance was taken alone.[7] MSM has also been shown to be effective in combination with bowellic acids.[8]

Athletes participating in a half marathon in 2017 demonstrated a decrease in muscle and joint pain post-race using MSM.[9]


Boswellia extracts can be an effective painkiller and have anti-inflammatory properties that may prevent the loss of cartilage. Research shows that boswellic acid can prevent the formation of leukotrienes in the body.[10] Leukotrienes are molecules that have been identified as a cause of inflammation which may inhibit the autoimmune process. A study done in 2003 reported decrease in knee pain, increased knee flexion and increased walking distance.


Studies show that curcumin, a chemical in turmeric, can act as a natural painkiller and may play a central role in pain management. This spice is effective for reducing joint pain and swelling by blocking inflammatory cytokines and enzymes.

A 2010[11] clinical trial using a turmeric supplement showed long-term improvement in pain and function in patients with knee OA. A small 2012 study using a curcumin product, BCM-95, showed more reduced joint pain and swelling in patients with active RA when compared with diclofenac sodium. According to one study out of India, taking curcumin was even more effective at reducing joint swelling and tenderness.[12]

Ginger Root

Taken daily, ginger has been shown to work about as well as ibuprofen for hip and knee arthritis pain. Ginger has been shown to have anti-inflammatory properties similar to ibuprofen and COX-2 inhibitors (e.g., Celebrex).[13] In a 2012 study[14], a specialized ginger extract was as effective in reducing inflammatory reactions in RA as steroids. Earlier studies showed that taking a certain extract four times daily reduced osteoarthritis pain in the knee after three months of treatment, and another taken twice daily worked about as well as ibuprofen taken three times daily for hip and knee OA pain.

Because of its ability to reduce inflammation, adding ginger to your diet could help treat both muscle pain and arthritis-related joint pain. 

Vitamin D3 

This vitamin builds and maintains strong bones, aids with calcium absorption and may help prevent osteoporosis.

Research has found that vitamin D may play a significant role in joint health, and that low levels may increase the risk of osteoarthritis and rheumatoid arthritis. Study authors also found the vitamin D deficiency was linked to arthritis paid as well.[15][16][17][18][19][20][21],[22],[23][24]


Research Studies 

[1] Jean-Yves Reginster,¬†Audrey Neuprez,¬†Marie-Paule Lecart,¬†Nathalie Sarlet, and¬†Olivier Bruyere. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012 Oct; 32(10): 2959‚Äď2967.

[2] Bruyère. Pharmaceutical-grade chondroitin sulfate in the management of knee osteoarthritis. Expert Opin Pharmacother. 2018 Mar;19(4):409-412.

[3] Martel-Pelletier J, Raynauld JP, Mineau F, Abram F, Paiement P, Delorme P, Pelletier JP. Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study. Arthritis Res Ther. 2017 Jul 20;19(1):169.

[4] Hochberg M, Chevalier X, Henrotin Y, Hunter DJ, Uebelhart D. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what's the evidence?
Curr Med Res Opin. 2013 Mar;29(3):259-67.

[5] M.C.Hochberg. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration.Osteoarthritis and Cartilage,2010 June; 18 (1): S28-S31.

[6] Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.Osteoarthritis and Cartilage. 2006 Mar;14(3):286-94.

[7] Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63.

[8] Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A, Moretti B. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial.Int J Immunopathol Pharmacol. 2016 Mar;29(1):140-6.

[9] Eric D. Withee, Kimberly M. Tippens, Regina Dehen, Deanne Tibbitts, Douglas Hanes, and Heather Zwickey. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017; 14:24.

[10] Krishanu¬†Sengupta, Krishnaraju¬†V¬†Alluri, Andey¬†Rama¬†Satish, Simanchala¬†Mishra, Trimurtulu¬†Golakoti, Kadainti¬†VS¬†Sarma,Dipak¬†Dey¬†and Siba¬†P¬†Raychaudhuri. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin¬ģ for treatment of osteoarthritis of the knee. Arthritis Research & Therapy 2008; 10:R85.

[11] Y.Henrotin, A.L.Clutterbuck, D. Allaway, E.M. Lodwig, P. Harris, M. Mathy-Hartert, M. Shakibaei. Biological actions of curcumin on articular chondrocytes. Osteoarthritis and Cartilage2010 Feb.; 18(2) 141-149. 

[12] Binu Chandran, Ajay Goel. A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis 2012, Mar.

[13] E.M.Bartels, V.N.Folmer, H.Bliddal, R.D.Altman, C.Juhl, S.Tarp, W.Zhang, R.Christensen. Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis and Cartilage 2015; 23(1): 13-21

[14] S√łren Ribel-Madsen,¬†Else Marie Bartels, Anders Stockmarr,¬†Arne Borgwardt,¬†Claus Cornett,¬†Bente Danneskiold-Sams√łe,¬†and¬†Henning Bliddal. A Synoviocyte Model for Osteoarthritis and Rheumatoid Arthritis: Response to Ibuprofen, Betamethasone, and Ginger Extract‚ÄĒA Cross-Sectional¬†In Vitro¬†Study. Arthritis2012; 505842.

[15] Gatenby P1, Lucas R, Swaminathan A. Vitamin D deficiency and risk for rheumatic diseases: an update. Curr Opin Rheumatol. 2013 Mar; 25(2):184-91.

[16] Goula T, Kouskoukis A, Drosos G, Tselepis AS, Ververidis A, Valkanis C, Zisimopoulos A, Kazakos K. Vitamin D status in patients with knee or hip osteoarthritis in a Mediterranean country. J Orthop Traumatol. 2015 Mar;16(1):35-9.

[17] Laslett LL, Quinn S, Burgess JR, Parameswaran V, Winzenberg TM, Jones G, Ding C. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2014 Apr;73(4):697-703.

[18] Jansen JA, Haddad FS. High prevalence of vitamin D deficiency in elderly patients with advanced osteoarthritis scheduled for total knee replacement associated with poorer preoperative functional state. Ann R Coll Surg Engl. 2013 Nov;95(8):569-72. 

[19] Veronese N, Maggi S, Noale M2 De Rui M, Bolzetta F, Zambon S, Corti MC, Sartori L, Musacchio E, Baggio G, Perissinotto E, Crepaldi G, Manzato E, Sergi G. Serum 25-Hydroxyvitamin D and Osteoarthritis in Older People: The Progetto Veneto Anziani Study. Rejuvenation Res. 2015 Dec;18(6):543-53.

[20] Rosecrans R, Dohnal JC. Seasonal vitamin D changes and the impact on health risk assessment. Clin Biochem. 2014 May;47(7-8):670-2.

[21] Laura Tripkovic, Helen Lambert,¬†Kathryn Hart,¬†Colin P Smith,¬†Giselda Bucca,¬†Simon Penson,¬†Gemma Chope,¬†Elina Hypp√∂nen,¬†Jacqueline Berry,¬†Reinhold Vieth, and¬†Susan Lanham-New. Comparison of vitamin D2¬†and vitamin D3¬†supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012 Jun; 95(6): 1357‚Äď1364.

[22] Manoy P, Yuktanandana P, Tanavalee A, Anomasiri W, Ngarmukos S, Tanpowpong T, Honsawek S. Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients 2017 Jul 26;9(8).

[23] Brennan-Speranza TC, Mor D, Mason RS, Bartlett JR, Duque G, Levinger I, Levinger P. Skeletal muscle vitamin D in patients with end stage osteoarthritis of the knee. J Steroid Biochem Mol Biol. 2017 Oct;173:180-184.

[24] Boyan BD, Hyzy SL, Pan Q, Scott KM, Coutts RD, Healey R4, Schwartz Z. 24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats. PLoS One2016 Aug 30;11(8):e0161782.